Differential Diagnosis

Differential Diagnosis

Differential Diagnosis

Differential diagnosis compiles potential causes, then eliminates them based on clinical evidence until the most probable remains. In litigation the process is often termed differential etiology because it addresses cause rather than diagnosis.

Courts generally accept it as a reliable methodology when properly performed.

Alternative Names:

Differential Etiology, Ruling In and Ruling Out

Why it Matters?

Admissibility turns on whether the expert actually performed both steps. Ruling in requires evidence that the proposed cause is capable of producing the condition, which depends on general causation. Ruling out requires addressing plausible alternatives rather than dismissing them summarily. An expert who ruled in the defendant's product without general causation support, or who failed to address obvious alternatives such as smoking or idiopathic occurrence, is vulnerable.

Frequently asked questions

What are the two steps of differential diagnosis?

What are the two steps of differential diagnosis?

Ruling in potential causes capable of producing the condition, then ruling out alternatives based on the individual's clinical evidence and history.

What is the most common basis for exclusion?

What is the most common basis for exclusion?

Failure to adequately rule out plausible alternative causes, or ruling in a cause without general causation support that it can produce the condition.